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Apply These Secret Techniques To Improve Pregnancy Loss And Chromosome Testing For Miscarriages

Although most couples are blissfully unaware of the statistics surrounding miscarriage, pregnancy loss is actually quite common, with 10-25% of recognized pregnancies ending in miscarriage. Should you have suffered a pregnancy loss or are currently in the process of experiencing a miscarriage, you could be wondering what caused the loss and worry about whether it will happen again. This article aims to answer the next questions:

What causes miscarriage?
How common is pregnancy loss?
Which kind of genetic testing is available for miscarriage tissue?
How can chromosome testing help?
Causes of Miscarriage

There are many different reasons why miscarriage occurs, but the most typical cause for first trimester miscarriage is a chromosome abnormality. Chromosome abnormalities – extra or missing whole chromosomes, also called “aneuploidy” – occur because of a mis-division of the chromosomes in the egg or sperm involved in a conception. Typically, humans have 46 chromosomes that come in 23 pairs (22 pairs numbered from 1 to 22 and the sex chromosomes, X and Y). For a child to develop normally it is important that it have the right level of chromosome material; missing or extra material at the time of conception or in an embryo or fetus can cause a woman to either not become pregnant, miscarry, or have a child with a chromosome syndrome such as for example Down syndrome.

Over 50% of most first trimester miscarriages are caused by chromosome abnormalities. stillbirth This number could be closer to 75% or more for women aged 35 years and over who’ve experienced recurrent pregnancy loss. Overall, the rate of chromosome abnormalities and the rate of miscarriage both increase with maternal age, with a steep upsurge in women older than 35.

Pregnancy Loss – How Common could it be?

Miscarriage is far more common than a lot of people think. Up to one atlanta divorce attorneys four recognized pregnancies is lost in first trimester miscarriage. The chance of having a miscarriage also increases as a mother gets older.

Most women who experience a miscarriage continue to get a healthy pregnancy rather than miscarry again. However, some women seem to be more prone to miscarriage than others. About five percent of fertile couples will experience two or more miscarriages.

Of note, the rate of miscarriage seems to be increasing. One reason for this may be awareness – more women know they are having a miscarriage because home pregnancy tests have improved early pregnancy detection rates over the past decade, whereas in past times the miscarriage would have were just a unique period. Another reason could be that more women are conceiving at older ages.

Types of Genetic Testing Ideal for Miscarriages

Genetic testing actually refers to many types of testing that can be done on the DNA in a cell. For miscarriage tissue, also called products of conception (POC), the most useful type of test to execute is really a chromosome analysis. A chromosome analysis (also known as chromosome testing) can examine all 23 pairs of chromosomes for the presence of extra or missing chromosome material (aneuploidy). Because so many miscarriages are due to aneuploidy, chromosome analysis on the miscarriage tissue can often identify the reason behind the pregnancy loss.

The most common approach to chromosome analysis is called karyotyping. Newer methods include advanced technologies such as microarrays.

Karyotyping analyzes all 23 pairs of chromosome but requires cells from the miscarriage tissue to first be grown in the laboratory, a process called “cell culture”. Because of this requirement, tissue that’s passed at home is frequently unable to be tested with this particular method. About 20% or even more of miscarriage samples fail to grow and thus no email address details are available. Additionally, karyotyping is unable to tell the difference between cells from the mother (maternal cells) and cells from the fetus. If a normal female result is found, it may be the correct result for the fetus or it can be maternal cell contamination (MCC) where the result actually comes from testing the mother’s cells present in the pregnancy tissue rather than the fetal cells. MCC seems to occur in about 30% or even more of the samples tested by traditional karyotype. Results from karyotyping usually take a few weeks to months another from the laboratory.

Microarray testing is a new kind of genetic testing done on miscarriage samples; the two most common forms of microarray testing are array CGH (comparative genomic hybridization) and chromosome SNP (single-nucleotide polymorphism) microarray. Microarray testing can be able to test all 23 pairs of chromosomes for aneuploidy, but will not require cell culture. Therefore, you’re more likely to receive results and the outcomes are usually returned faster when microarray testing is used. Additionally, some laboratories are collecting a sample of the mother’s blood as well the miscarriage tissue is delivered to enable immediate detection of maternal cell contamination (MCC).

Chromosome Testing – How do it help?

In case a chromosome abnormality is identified, the kind of abnormality found can be assessed to help answer the question: “Will this eventually me again?”. Most of the time, chromosome abnormalities within an embryo or fetus aren’t inherited and have a low chance to occur in future pregnancies. Sometimes, a particular chromosome finding in a miscarriage alerts your physician to do further studies to research the possibility of an underlying genetic or chromosome problem in your family that predisposes one to have miscarriages.

Furthermore, if a chromosome abnormality is identified it can prevent the need for other, sometimes quite costly, studies your doctor might consider to investigate the reason for the miscarriage.

Lastly, knowing the reason behind a pregnancy loss can help a couple of start the emotional healing process, moving past the question of “Why did this eventually me?”.

Chromosome testing could be especially important for patients with repeated miscarriages, as it could either give clues to an underlying chromosomal cause for the miscarriages or rule out chromosome errors as the reason for the miscarriages and allow their doctor to pursue other types of testing. For couples with multiple miscarriages determined to have a chromosomal cause, in vitro fertilization (IVF) with preimplantation genetic diagnosis (PGD) testing may be able to help increase their likelihood of having an effective healthy pregnancy.