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Apply These Secret Techniques To Improve Pregnancy Loss And Chromosome Testing For Miscarriages

Although most couples are blissfully unaware of the statistics surrounding miscarriage, pregnancy loss is really quite common, with 10-25% of recognized pregnancies ending in miscarriage. Assuming you have suffered a pregnancy loss or are currently in the process of having a miscarriage, you might be wondering what caused the loss and worry about whether it will happen again. This article aims to answer the next questions:

What causes miscarriage?
How common is pregnancy loss?
What sort of genetic testing can be acquired for miscarriage tissue?
How can chromosome testing help?
Causes of Miscarriage

There are many different explanations why miscarriage occurs, but the most typical cause for first trimester miscarriage is a chromosome abnormality. Chromosome abnormalities – extra or missing whole chromosomes, also known as “aneuploidy” – occur due to a mis-division of the chromosomes in the egg or sperm involved in a conception. Typically, humans have 46 chromosomes which come in 23 pairs (22 pairs numbered from 1 to 22 and the sex chromosomes, X and Y). For a baby to develop normally it is important that it have the right quantity of chromosome material; missing or extra material at the time of conception or within an embryo or fetus can cause a female to either not become pregnant, miscarry, or have a baby with a chromosome syndrome such as Down syndrome.

Over 50% of most first trimester miscarriages are caused by chromosome abnormalities. This number could be closer to 75% or more for women aged 35 years and over who have experienced recurrent pregnancy loss. Overall, the rate of chromosome abnormalities and the rate of miscarriage both increase with maternal age, with a steep upsurge in women older than 35.

Pregnancy Loss – How Common could it be?

Miscarriage is far more common than a lot of people think. Up to one in every four recognized pregnancies is lost in first trimester miscarriage. The chance of experiencing a miscarriage also increases as a mother gets older.

Nearly all women who experience a miscarriage continue to have a healthy pregnancy and never miscarry again. However, some women seem to be more susceptible to miscarriage than others. About five percent of fertile couples will experience several miscarriages.

Of note, the rate of miscarriage appears to be increasing. One reason for this may be awareness – more women know they’re having a miscarriage because home pregnancy tests have improved early pregnancy detection rates in the last decade, whereas during the past the miscarriage would have appeared to be just a unique period. Another reason could be that more women are conceiving at older ages.

Types of Genetic Testing Ideal for Miscarriages

Genetic testing actually identifies many different types of testing that you can do on the DNA in a cell. For miscarriage tissue, also known as products of conception (POC), the most useful type of test to execute is a chromosome analysis. A chromosome analysis (also known as chromosome testing) can examine all 23 pairs of chromosomes for the current presence of extra or missing chromosome material (aneuploidy). Because so many miscarriages are due to aneuploidy, chromosome analysis on the miscarriage tissue can often identify the reason behind the pregnancy loss.

The most common approach to chromosome analysis is called karyotyping. Newer methods include advanced technologies such as for example microarrays.

Karyotyping analyzes all 23 pairs of chromosome but requires cells from the miscarriage tissue to first be grown in the laboratory, an activity called “cell culture”. Because of this requirement, tissue that is passed at home is often unable to be tested with this method. About 20% or even more of miscarriage samples fail to grow and thus no email address details are available. Additionally, karyotyping is unable to tell the difference between cells from mom (maternal cells) and cells from the fetus. If a normal female result is available, it may be the right result for the fetus or it might be maternal cell contamination (MCC) in which the result actually comes from testing the mother’s cells within the pregnancy tissue instead of the fetal cells. MCC seems to occur in about 30% or even more of the samples tested by traditional karyotype. Results from karyotyping usually take a few weeks to months another from the laboratory.

Microarray testing is really a new type of genetic testing done on miscarriage samples; the two most common types of microarray testing are array CGH (comparative genomic hybridization) and chromosome SNP (single-nucleotide polymorphism) microarray. Microarray testing can be in a position to test all 23 pairs of chromosomes for aneuploidy, but does not require cell culture. Therefore, you are more likely to receive results and the outcomes are usually returned faster when microarray testing is used. stillbirth Additionally, some laboratories are collecting a sample of the mother’s blood concurrently the miscarriage tissue is sent to enable immediate detection of maternal cell contamination (MCC).

Chromosome Testing – How do it help?

If a chromosome abnormality is identified, the type of abnormality found could be assessed to help answer fully the question: “Will this eventually me again?”. Most of the time, chromosome abnormalities within an embryo or fetus aren’t inherited and have a minimal possiblity to occur in future pregnancies. Sometimes, a particular chromosome finding in a miscarriage alerts your physician to do further studies to research the possibility of an underlying genetic or chromosome problem in your family that predisposes one to have miscarriages.

Furthermore, if a chromosome abnormality is identified it can prevent the dependence on other, sometimes quite costly, studies your doctor might consider to investigate the reason for the miscarriage.

Lastly, knowing the reason behind a pregnancy loss might help a couple of start the emotional healing process, moving at night question of “Why did this eventually me?”.

Chromosome testing could be especially important for patients with repeated miscarriages, as it could either give clues to an underlying chromosomal cause for the miscarriages or rule out chromosome errors as the reason for the miscarriages and allow their doctor to pursue other types of testing. For couples with multiple miscarriages determined to truly have a chromosomal cause, in vitro fertilization (IVF) with preimplantation genetic diagnosis (PGD) testing may be able to help increase their chances of having an effective healthy pregnancy.